"Must Be Love" follows the love story of Patricia, better known as "Patchot" played by (Kathryn Bernardo) and her childhood best friend Ivan (Daniel Padilla). But what will Patchot do if she starts falling in love with her best friend?. And what if Ivan only sees her as a 'best friend'? This problem will develop when another girl enters Ivan's life. Unfortunately for Patchot, it's her cousin Angel. Will Ivan fall in love with "Patch" or will they remain as best friends forever?